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چکیده
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It is of key importance to design efficient insulin electrocatalysts based on nonprecious noble metal-free. However, the design of advanced nanostructured based metal phosphides is scarcely reported. In this work, for the first time, a novel insulin sensor based on Ni2P electrode materials with nanoplate structure was designed. In this regard, Hofmann-type coordination polymers (HCPs) based on Ni(H2O)2[Ni(CN)4]·H2O (Ni–Ni HCP) were prepared and used as precursors to the preparation of Ni2P. The unique layer structure of Ni–Ni HCP precursors can lead to the preparation of Ni2P nanoplates with large surface areas, high availability of active catalytic centers, and abundant interior space for fast diffusion and boosted reaction kinetics. The electrochemical results showed that the Ni2P nanoplates offer excellent capability toward insulin oxidation in 0.1 M NaOH electrolyte solution. Moreover, a proper linear relationship was obtained between insulin concentrations and the current responses in the range of 10 to 100 pM with the detection limit of 3 pM and with good capability for the determination of insulin in the human blood serum sample. This work offers a rational method for the structure engineering of Ni2P nanoplates using HCP precursors, which can lead to the fabrication of high-performance insulin sensor.
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