عنوان	Study of inclusion complex formation between chlorpromazine hydrochloride, as an antiemetic drug, and β-cyclodextrin, using conductometric technique
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Micellization Inclusion complex Chlorpromazine hydrochloride Cyclodextrin Conductometry
چکیده	The behavior of micellization of chlorpromazine hydrochloride (CPH) as an antiemetic drug and its inclusion complex formation with β-cyclodextrin (β-CD) was studied using conductometric technique. The binding or association constant of the complexation equilibrium is evaluated from conductometric measurements by using a nonlinear regression method. The resulting K values for micellization as well as complexation are analyzed. The experiments were carried out at different temperatures. It has been found that CPH form only the 1:1 complex. The association constant values are used for evaluation of thermodynamic parameters of complexation, such as ΔGcomplex°, ΔHcomplex° and ΔScomplex°.
پژوهشگران	انسیه قاسمیان لمراسکی (نفر اول)، Amir AbbasRafati (نفر دوم)، NazaninHamnabard (نفر سوم)، Zabiolah BolboliNojini (نفر چهارم)