عنوان	Visfatin reduces hippocampal CA1 cells death and improves learning and memory deficits after transient global ischemia/reperfusion
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Visfatin, Apoptosis, Passive avoidance memory, Transient global cerebral ischemia
چکیده	Visfatin is a novel adipocytokine with insulin-mimetic effect which plays a role in glucose-lowering effect of insulin and improves insulin sensitivity. It has been linked to a variety of cellular processes and its plays important roles in cell apoptosis and survival. Moreover, cerebral ischemia causes loss of hippocampus pyramidal cells, therefore, in this study; we investigated the neuroprotective effect of visfatin after global cerebral ischemia in male rats. Both common carotid arteries were occluded for 20 minutes followed by 4 days of reperfusion. Animals were treated with either the Visfatin (intracerebroventricular; 100 ng) or saline vehicle (2 μl) at the time of reperfusion. Behavioral examination, apoptosis and necrosis assessment were performed 4 days after ischemia. Visfatin significantly reduced Caspase-3 activation (P < 0.001), TUNEL positive cells (P < 0.05) and necrotic cell death in the CA1 region of the hippocampus (P < 0.001). Moreover, treatment with visfatin significantly improved memory deficits of cerebral ischemia–reperfusion rats (P < 0.05). The results suggest that visfatin via its antiapoptotic properties has significant neuroprotective effects on cerebral ischemia reperfusion injury in rats.
پژوهشگران	سهیلا عرفانی (نفر اول)، مهدی خاکساری (نفر دوم)، شهربانو عریان (نفر سوم)، نبی شمسایی (نفر چهارم)، ناهید ابوطالب (نفر پنجم)، فرناز نیکبخت (نفر ششم به بعد)، نیدا جمالی رئوفی (نفر ششم به بعد)، فاضل گرجی پور (نفر ششم به بعد)