عنوان	Activation of the unfolded protein response and alternative splicing of ATF6α in HLA-B27 positive lymphocytes
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Endoplasmic reticulum,Unfolded protein response,MHC,Transcription factor,Protein folding
چکیده	Misfolding of major histocompatibility complex (MHC) class I molecules has been implicated in the rheumatic autoimmune disease ankylosing spondylitis (AS), and has been linked to the unfolded protein response (UPR) in rodent AS models. XBP1 and ATF6α are two important transcription factors that initiate and co-ordinate the UPR. Here we show that misoxidised MHC class I heavy chains activate XBP1 processing in a similar manner to tunicamycin, with tunicamycin and dithiothreitol (DTT) inducing differential XBP1 processing. Unexpectedly, ATF6α mRNA is alternatively spliced during reducing stress in lymphocytes. This shorter ATF6α message lacks exon 7 and may have a regulatory role in the UPR
پژوهشگران	اندره لمن (نفر اول)، خلیل سالکی (نفر دوم)، مارسل ون لث (نفر سوم)، ادم بنهم (نفر چهارم)