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چکیده
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Abstract This study was designed to examine the eVects of intracerebroventricular (ICV) injection of bicuculline (GABAA receptor antagonist) and muscimol (GABAA receptor agonist) on glutamate-induced eating response in 24-h food-deprived (FD24) broiler cockerels. At Wrst, guide cannula was surgically implanted in the right lateral ventricle of chickens. In experiment 1, birds were ICV injected with diVerent doses of glutamate. In experiment 2, birds were administered with eVective dose of glutamate after bicuculline. In experiment 3, chickens received muscimol prior to the injection of glutamate, and cumulative food intake was determined at 3-h postinjection. The results of this study showed that glutamate decreases food consumption in FD24 broiler cockerels (P · 0.05), and this reduction occurs in a dose-dependent manner. Moreover, the inhibitory eVect of glutamate on food intake was signiWcantly increased with bicuculline pretreatment, and this eVect was attenuated with muscimol (P · 0.05). These results suggest that there is an interaction between glutamatergic and GABAergic systems (through GABAA receptor) on food intake in broiler cockerels.
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