عنوان	Two-Dimensional Mesoporous Copper Hydroxide Nanosheets Shelled on Hollow Nitrogen-Doped Carbon Nanoboxes as a High Performance Aptasensing Platform
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	hollow carbonaceous nanostructures, metal hydroxide nanosheets, copper hydroxide nanosheets, electrochemical aptasensor, trypsin
چکیده	The design of metal hydroxide nanosheets on hollow carbonaceous nanostructures has attracted immense attention because of their unparalleled physical/chemical properties with sizeable intrinsic capability to load specific chemicals. Herein, a novel metal hydroxide based on hollow nitrogen-doped carbon nanoboxes shelled with a nanoporous copper hydroxide nanosheet (Cu(OH)2@N−C n-box) was fabricated. The structure of fabricated hollow nanomaterials was fully characterized by various physicochemical characterization techniques such as field emission scanning electron microscopy (FESEM), high-resolu1tion transmission electron microscopy (HRTEM), Brunauer−Emmett−Teller (BET) method, thermogravimetric analysis (TGA), powder X-ray diffraction (XRD), and Fouriertransform infrared (FTIR) and Raman spectroscopies, which confirmed that a complex core−shell structure with ordered two-dimensional Cu(OH)2 nanostructures on N−C n-box was successfully prepared. The Cu(OH)2@ N−C n-box is used to fabricate an advanced electrochemical aptasensor to measure the protein enzyme trypsin. In addition, it acts as an excellent substrate with abundant functional groups and a large surface area for fixing and bonding aptamers on the modified glass-carbon surface. Each step of electrode surface modification was investigated through ferro/ferri cyanide probe signal changes. The designed aptasensor can determine trypsin in a linear concentration between 10 to 80 pg/mL and 10 to 80 ng/mL with a detection limit of 3 pg/mL. The proposed system also has a desirable selectivity in the presence of different interferences. This is the first report on the rational design of hollow carbonaceous materials hybridized Cu(OH)2 for the electrochemical application
پژوهشگران	محمود روشنی (نفر اول)، هادی حسینی (نفر دوم)، بهناز پاکزاد (نفر سوم)، زینب رحمتی (نفر چهارم)