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چکیده
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Organic sulfides are important compounds which widely exist in many biologically and pharmaceutically active molecules. Especially sulfides moieties have been used in the treatment diseases such as Parkinson,s, Alzheimer,s, immune and inflammatory, diabetes, HIV.The formation of carbon-sulfur bond has been widely examined and generally from nano particles catalyzed for coupling bond C-S have been used for the formation this bond., For example disulfide bondes have been employed in stabilization of peptides in proteins, DNA cleaving and design of drug delivery systems [1]. Copper nanoparticles catalyst was easily isolated from the reaction mixture by simple filtration and reused with loss in activity Using nontoxic and nano catalyst, simplified operational process, short reaction times purification of the products without using chromatographic separation, and environmentally, and excellent yield [2]. As part of our current studies on the synthesis of organosulfurs compounds, we report the results of our studies involving the reaction between aryl halides with 1,3,4-Thiadiazol- 2,5dithiol in the present of copper nanoparticles as a catalyst, KOH as a base at 100 oC in Wet Appropriate solvent . High yields were obtained and cooper nanoparticles catalyst was easily isolated from the reaction mixture by simple filtration and reused with loss in activity.
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