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چکیده
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Sulfamethoxazole is a widely used sulfonamide antibiotic, but its overdose can cause serious side effects, underscoring the need for sensitive and selective detection methods. In this work, we introduce a selective and novel electrochemical sensor based on a bimetallic CeBi-metal organic framework integrated with carbon nanotubes and Ketjen black nanocomposite for the efficient determination of sulfamethoxazole. The CeBi- metal organic framework was synthesized via a facile hydrothermal method, and the resulting nanocomposite was fabricated through an ultrasonic-assisted strategy to form an interconnected conductive network. Benefiting from the synergistic effects of the bimetallic metal organic framework (high surface area and abundant active sites) and the ketjen black and carbon nanotubes matrix (superior electrical conductivity and electron-transfer capability), the proposed sensor exhibits outstanding analytical performance. It offers a wide linear response range from 0.5 to 3000 nM, with an exceptionally low detection limit of 0.042 nM. Moreover, the sensor demonstrates excellent reproducibility, stability, repeatability, and selectivity. Practical applicability was successfully validated by detecting sulfamethoxazole in the blood serum samples with satisfactory recoveries (97–104%). This work presents, for the first time, the use of a CeBi-metal organic framework and ketjen black/carbon nanotubes nanocomposite as an electrochemical platform for sulfamethoxazole detection, providing a simple, cost-effective, and highly selective alternative to conventional techniques. The developed sensor holds great promise for pharmaceutical and clinical monitoring applications.
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