In this article, a new dual template molecularly imprinted polymer (DT-MIP) based on modified magnetic graphene oxide was synthesized and employed for the determination of organic compounds by a dispersive micro-solid phase extraction (DMSPE) method. The imprinted layer was introduced on the surface of a core–shell magnetic modified graphene oxide as a substrate. molecularly imprinted polymers (MIPs) with predictable structures, specific recognition abilities and universal applications have become attractive adsorbents and have been widely applied in sample pretreatment and chromatographic separation to specifically extract the template molecules from complex matrices [1-4]. The sorbent was characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), vibrating sample magnetometry (VSM), X-ray powder diffraction (XRD), energy dispersive X-ray (EDX) and methods. The effects of various parameters such as the pH, ionic strength of the sample solution, amount of sorbent (mg), volume of eluent solvent (mL), vortex time, and ultrasound time (min) were optimized by a Box–Behnken design. Under optimum conditions, the calibration graph of the analyte was linear in the concentration range of 1–300 µg L-1, with a correlation of determination (r2) of 0.9927. The limit of detection and quantification were 0.2 and 0.66 µg L-1, respectively. This procedure was successfully applied to the determination of the analyte in a real sample and spiked real sample followed by high performance liquid chromatography (HPLC) analysis. The relative mean recoveries ranged from 95 to 104%.
