Palladium S-methylisothiourea [Pd(0)- SMT] has been grafted at the surface of functionalized mesoporous silica MCM-41 and used as an efcient and reusable heterogeneous nanocatalyst system for amination of various aryl halides and the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives. The present methodology offers several advantages such as simplicity of procedure, easy isolation of the products and reused for several consecutive runs without signifcant loss of their catalytic efciency. The characteristic structural features of this new catalyst was determined by various physicochemical techniques such as FT-IR spectroscopy, XRD, SEM/EDS, ICP, TGA, BET surface area measurement and elemental analysis.
