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Arash Ghorbani-Choghamarani

Academic rank: Professor
ORCID:
Education: PhD.
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Faculty: Basic Science
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Research

Title
One-pot, Green and Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones or Thiones Catalyzed by Citric Acid
Type
JournalPaper
Keywords
Biginelli reaction; One-pot synthesis; 3,4-Dihydropyrimidin-2(1H)-ones; Citric acid.
Year
2013
Journal JOURNAL OF THE CHINESE CHEMICAL SOCIETY
DOI
Researchers Arash Ghorbani-Choghamarani ، Tahereh Taghipour ، Gouhar Azadi

Abstract

One-pot three-component condensation of ethyl acetoacetate, aldehyde and urea or thiourea in refluxing ethanol in the presence of catalytic amounts of citric acid afforded the corresponding 3,4-dihydropyrimidin-2(1H)-ones/thiones in high yields. The catalyst is reusable and can be applied several times without any decrease in product yield.