The purpose of this study was to investigate the effect of Vitis vinifera (Vv extract) against imidacloprid (IC)-induced tissue insults and oxidative damages. Twenty-eight adult male Wistar rats were randomly distributed into four groups. Group 1 was regarded as the control group, group 2 received 90 mg/kg/day IC by gavage, group 3 received 90 mg/kg IC + 100 mg/kg Vv extract, and group 4 was treated with 100 mg/kg Vv extract. After 45 days, histological, biochemical, antioxidative, and inflammatory parameters were assessed. Results revealed that IC adversely affects both the histoarchitecture and the function of the kidney, liver, and testis. Also, treatment with IC significantly induces oxidative stress and inflammation. Otherwise, treatment with a combination of IC and Vv extract significantly attenuates oxidative stress and inflammation, improves organ physiology, and restores histological alterations induced by IC exposure. These findings provide new insights into the potential protective role of Vv extract and provide promising protection against IC intoxication in various organs.
