Imidazole derivatives have attracted significant attention in recent years due to their diverse therapeutic activities, including antibacterial, antifungal, antiviral, anti-inflammatory, antitubercular, antidepressant, and antitumor effects. Triarylimidazole compounds have gained notable significance owing to their broad range of biological activities and their utility in synthetic chemistry. The imidazole ring system is a crucial substructure that is commonly found in numerous natural products and pharmacologically active compounds. Examples of such compounds include the antiulcerative agent cimetidine, the proton pump inhibitor omeprazole, and the benzodiazepine antagonist flumazenil, all of which are derivatives of imidazole [1,2]. In this study, the synthesis of Zn0.5Ni0.5Fe2O4 magnetic nanoparticles by the sol-gel method was carried out. The resulting sample was characterized by FTIR, XRD, TEM, FESEM, EDX, and VSM. The catalytic activity of Zn0.5Ni0.5Fe2O4 MNPs was assessed for the synthesis of 2, 4, 5-triarylimidazole derivatives through a three-component reaction under microwave irradiation and solvent-free conditions. The obtained product was analyzed using 1H NMR and 13C NMR spectroscopy. This study offers several advantageous features, including the environmentally friendly and cost-effective synthesis of nanoparticles, utilization of microwave irradiation under solvent-free conditions, short reaction times, simple work-up procedures, and mild reaction conditions.
