traditional medicine for treatment of inflammations, gastrointestinal and menstrual disorders. Materials and Methods: In the current study, we assessed the efficacy of a hydroalcoholic extract from the A. tenuifolia for hepatoprotective properties and lipid-lowering effects on nonalcoholic fatty liver disease. 35 rats were divided randomly into control, high-fat diet (HFD) rats, and rats received high-fat diet plus a different dose of the A. tenuifolia extract for 6 weeks. Results: Oral administration of A. tenuifolia extract (100, 200 and 300 mg/kg) lowered body weights dramatically lesser than HFD group and promoted hepatic histology and enzymes and significantly reduced serum lipids and fasting glucose level in rats induced by HFD. A.tenuifolia supplementation increased antioxidant properties and decreased lipid peroxidation. Also, A. tenuifolia (200 mg/kg) significantly suppressed lipid accumulation in the liver, reduced serum lipid profile in HFD-fed rats. Conclusion: The present study showed that antioxidant properties of A. tenuifolia extract may represent a promising approach for the prevention and treatment of obesity-related nonalcoholic fatty liver disease.
