In this work boehmite nanoparticles (NPs) were synthesized from NaOH and Al(NO3)3.9H2O solutions. Then, the surface of boehmite NPs was modified by (3-chloropropyl)trimethoxysilane and further Schiff-base ligand (MP-bis(AMP)) was immobilized on its surface. At final step, a copper complex was stabilized on the surface of modified boehmite NPs (Cu(II)-MP-bis(AMP)@boehmite). These obtained nanoparticles were characterized using SEM, EDS, WDX, AAS, TGA, BET, FT-IR, and XRD techniques. In continue, the catalytic activity of Cu(II)-MP-bis(AMP)@boehmite has been investigated in the synthesis of biphenyl ether derivatives through C-O coupling reaction. C-O coupling reaction is a powerful tool for the synthesis of ether derivatives [1-4]. Cu(II)-MP-bis(AMP)@boehmite catalyst has been reused for several times in the synthesis of ether derivatives.