Synergistic compounds have shown effective results in improving oil production from oil reservoirs due to their high surface properties. In this laboratory study, a novel was prepared to alter the wettability and increase oil recovery. In this regard, the nanoparticle was first synthesized and then surface-modified with effective compounds. In the next step, it was prepared as a nanofluid using low-salinity water. The structural characteristics of the surface-modified synthetic nanoparticle were analyzed using SEM, FTIR and XRD. The stability of the nanofluid was investigated using zeta potential analysis. Additionally, interfacial tension, contact angle and core flooding tests were done. The results showed that the nanofluid reduced the contact angle and surface tension from the baseline values to 29° and 3.20 mN/m, respectively. The core flooding results indicated that the maximum oil recovery using the synthetic nanofluid was 15%.