Septoriosis is one of the important diseases of wheat in the world and Iran too. Considering the high cultivated area of wheat and the economic importance of this crop in Ilam province, the present study done with the aim of investigating the combined effects of Trichoderma fungus and epiphyte bacteria to reduce the damage caused by Septoria tritici on two Mehregan and Tajan varieties of wheat under greenhouse conditions. After 35 days, disease severity and growth characteristics of wheat including; Fresh and dry weight root (g), fresh and dry weight shoot (g) and plant height (cm) were evaluated in the presence of pathogenic fungus and biocontrol agents. The results of the traits correlation showed there was a positive and significant correlation between fresh and dry weight root, fresh and dry weight shoot and plant height. Also there was a negative and significant correlation between, disease severity and the fresh and dry weight of roots and shoots and plant height. The t-test results between Mehregan and Tajan cultivars showed the disease severity in Tajan cultivar was lower than Mehregan. The highest fresh and dry weight root, fresh and dry weight shoot and plant height were obtained for Tajen variety.