An effective and green one-pot multicomponent reaction for the synthesis of pyrrolo[1,2-a]pyrazine derivatives by Fe3O4@SiO2-OSO3H as a reusable magnetic nanocatalyst has been reported. Pyrrolo[1,2-a]pyrazine derivatives are achieved reaction among ethylenediamine, dialkylacetylenedicarboxylates and β-nitrostyrene derivatives in water as a green solvent with high to excellent yields. This catalyst was characterized by FT-IR, SEM (scanning electron microscopy), EDX (energy dispersive X-ray spectroscopy), VSM (vibrating sample magnetometry) and XRD (X-ray diffraction) techniques
