A new and mild protocol for the synthesis of pyrazolopyranopyrimidines using CoFe2O4@SiO2-PA-CC-Guanidine MNPs in water at room temperature was reported. Pyrazolopyranopyrimidine derivatives were synthesized from reaction between hydrazine hydrate, ethylacetoacetate, aldehydes and barbituric acid derivatives in good to excellent yields. This nanocatalyst was characterized by FT-IR spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), Thermogravimetric analysis (TGA) and vibrating sample magnetometry (VSM) techniques. CoFe2O4@SiO2-PA-CC-Guanidine MNPs have high activity and easy separation from the reaction mixture. This magnetic nanocatalyst has recovery capability and can be reused for the several times.
