In this study, the synthesis of pyrido[2,3-d:5,6-d ]dipyrimidines using CoFe2O4@SiO2-PA-CC-guanidine-SA magnetic nanoparticles with excellent yields has been reported. Pyrido[2,3-d:5,6-d]dipyrimidines were synthesized from the four-component reaction of barbituric acid derivatives, benzaldehyde derivatives and ammonium acetate in water at room temperature. The synthesized catalyst was identified using Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray powder diffraction (XRD), thermogravimetric analysis (TGA) and vibrating sample magnetometer (VSM) techniques.
