2025 : 9 : 29

Masoud Baghelani

Academic rank: Associate Professor
ORCID:
Education: PhD.
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Faculty: Engineering
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Research

Title
Al-Mo nanocomposite functionalization for membrane-basedresonance detection of bovine Herpesvirus-1
Type
JournalPaper
Keywords
AlMo membrane,4-formylbenzene diazonium,hexafluorophosphate,Bovine herpesvirus-1,Biosensor
Year
2020
Journal SENSORS AND ACTUATORS A-PHYSICAL
DOI
Researchers Remko van den Hurka ، Masoud Baghelani ، Jie Chena ، Mojgan Daneshmanda ، Stephane Evoyaa

Abstract

tThe functionalization of a nanocomposite AlMo surface with a bifunctional diazonium linker is pre-sented. Binding of diazonium molecules to the AlMo surface was validated through XPS measurementsof 4-bromobenzenediazonium tetrafluoroborate and the linking molecule 4-formylbenzene diazoniumhexafluorophosphate. The linker was then used to bind monoclonal antibodies specific for bovineherpesvirus-1 (BHV-1) to the AlMo coated chips. BHV-1 was successfully captured on the chip surface.The functionalization process was then implemented on 10 nm thick AlMo membranes and resonancemeasurements were performed to successfully detect BHV-1. A method for calculating the mass of BHV-1on the surface of the membranes is presented and validated via finite element analysis.