In this paper, Pd–cytosine complex immobilized on functionalized hexagonal mesoporous silica (HMS– CPTMS–Cy–Pd) as a novel mesoporous catalyst with high activity for the Stille and Suzuki coupling reactions was successfully fabricated. All products were obtained in good to excellent yields at low time reaction. The prepared catalyst has been characterized using various techniques such as FT-IR, XRD, BET, SEM, EDX-MAP, TGA and ICP. Recovery test confirm that the synthesized catalyst can be able to reuse for several times.