Mesoporous MCM-41 has unique properties such as large specific surface area homogeneous hexagonal pore, ease of functionalization, high thermal stability, relatively hydrophobic nature, simple preparation and easy separation from the reaction mixture [1]. Therefore, in this work, hexagonal arrangement mesoporous MCM-41 was synthesized and functionalized with a new Schiff base ligand. Then, a lanthanum complex was stabilized on the surface of modified mesoporous MCM-41 (La-Schiff base@MCM-41). The prepared La-Schiff base@MCM-41 was characterized by BET, SEM, WDX, EDS, XRD, and AAS techniques. Then, La-Schiff base@MCM-41 was used as a new catalyst in the homoselective synthesis of tetrazole derivatives. Because, tetrazoles were used in drugs and they are used as analgesics, herbicides, antimicrobial, anti-proliferative, anti-inflammatory, and anticancer agents [2-4]. For example, Valsartan, Losartan and TAK-456 are several pharmacologically important of tetrazoles [5]. Finally, the recyclability and reusability of this catalyst were investigated as an important principle in green chemistry.
