An efficient three-component reaction of aromatic aromatic aldehyde, 1,3-cyclohexanedione/dimedone, and ethyl acetoacetate and ammonium acetate have been developed as an atom-economic procedure catalyzed by a deep eutectic solvent [Urea][SnCl2]2. Conversion was high under optimal conditions. Other remarkable features include a much milder procedure, a shorter reaction time, a wide range of functional group tolerance, and absence of any tedious workup or purification. This procedure also avoids volatile organic and hazardous reagents/solvents and is thus an eco-friendly alternative to the existing methods.
