A recyclable and magnetic nanoparticles catalyst (Cu(II)- Histidine@ Fe3O4) was synthesized via grafting Histidine into magnetically functionalized Fe3O4 in ethanol. The properties of Cu(II)- Histidine@ Fe3O4 were fully characterized by powder X-ray diffraction, electron microscopy, TGA/DTA analysis, Fourier-transform infrared spectroscopy and a magnetic property measurement system. Cu(II)- Histidine@ Fe3O4 showed high activity in the synthesis of 2,3-dihydroquinazolin-4(1H)-one under mild conditions. Furthermore, the catalyst can be easily separated from the reaction mixture, and the recycled catalyst maintained high performance for several cycles.
