We report the elaboration of L-Histidinefunctionalized magnetic nanoparticlesthat can act as a new nanomagnetically catalyst. The catalytic performance of L-Histidine@Fe3O4 was evaluated in a three-component combination for the synthesis of tetrahydrobenzo[b]pyran derivatives via the condensation reaction of malononitrile, various aromatic aldehydes and dimedone in water. All reactions were completed in short times and all products were obtained in good to excellent yields. The L-Histidine@Fe3O4 could be recovered for 5 times efficiently.
