The whole preparation route to the TPPA-IL-Fe3O4 includes three steps as illustrated in Scheme 1. At first, the magnetite prepared by coprecipitation from Fe2+ and Fe3+ using NH3 solution. Then, the 3-aminopropyltriethoxysilane was added to the ethanolic solution of Fe3O4 nanoparticles to achive amino-coated Fe3O4 nanoparticles through coordination bond with hydroxyl group.