A sensitive hydrogen peroxide (H2O2) sensor was constructed based on copper nanoparticles/methylene blue/ multiwall carbon nanotubes–fullerene–chitosan–ionic liquid (CuNPs/MB/MWCNTs–C60–Cs–IL) nanocomposites. TheMB/MWCNTs–C60–Cs–IL and CuNPswere modified glassy carbon electrode (GCE) by the physical adsorption and electrodeposition of copper nitrate solution, respectively. The physical morphology and chemical composition of the surface of modified electrode was investigated by scanning electron microscopy (SEM) and energydispersive X-ray spectroscopy (EDS), respectively. The electrochemical properties of CuNPs/MB/MWCNTs–C60– Cs–IL/GCE were investigated by cyclic voltammetry (CV) and amperometry techniques and the sensor exhibited remarkably strong electrocatalytic activities toward the reduction of hydrogen peroxide. The peak currents possess a linear relationshipwith the concentration of H2O2 in the range of 0.2 μMto 2.0mM, and the detection limit is 55.0 nM (S/N = 3). In addition, the modified electrode was used to determine H2O2 concentration in human blood serum sample with satisfactory results.
