A novel molecularly imprinted polymer sensor for fast and direct determination of trazosine (TR) was studied. The voltammetric sensor based on molecularly imprinted polymer (MIP) with disposable gold nanoparticles modi ed screen printed carbon electrode (MIP/AuNPs/SPCE) is developed for the determination of TR. Under fi the optimum conditions, the peak current of the sensor and TR concentration showed a good linear relationship over the range from 2.0 to 250.0 M, with a low detection limit (S/N = 3) of 0.3 M. The modi ed electrode μ μ fi demonstrated good electrocatalytic properties toward the oxidation of TR. This sensor selectively detected TR even in the presence of high concentration of similar compounds and MIP/AuNPs/SPCE was also con rmed fi successfully for the determination of TR in the various real samples including human blood serum, urine and trazosin tablet.
