An electrochemical sensor was designed based on glassy carbon electrode (GCE) modified with Ni-metal organic framework/multi-walled carbon nanotubes (Ni-MOF/MWCNTs) for the detection of Ixazomib citrate (IXM) drug. Electrochemical tests were carried out on the modified electrode via electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV), and cyclic voltammetry (CV). The introduced sensor displayed excellent electrocatalytic response due to synergistic effect of MWCNTs and Ni-MOF. The designed electrode demonstrates wide linear range from 0.01 to 1000 nM, with detection limit (LOD) of 0.003 nM for IXM. This electrochemical platform displayed acceptable reproducibility, repeatability, and stability. The results prove the sensor’s potential for the selective detection IXM. Finally, the electrochemical sensor has a good potential for practical applications. In this sense, the designed sensor was used to detect IXM in actual sample with acceptable results.
