Organic sulfides are important compounds which widely exist in many biologically and pharmaceutically active molecules. Especially unsymmetrical sulfides moieties have been used in the treatment diseases such as Parkinson,s, Alzheimer,s, immune and inflammatory, diabetes, HIV [1,2]. Carbon-sulfur bond formation by cross-coupling reaction in the presence of transition metals has been widely investigated. Metal-organic frameworks (MOFs) have recently aroused much attention as a new class of nanoporous material that can used as an effective, heterogeneous, and recyclables in coupling reactions [3] As a part of our current studies on the synthesis of Organosulfurs compounts, we report the results of our studies involving the reaction between iodobenzene and thios in the presence MOF-199 as a catalyst, KOH in wet PEG(400) at 120 oC under an N2 atmosphere conditions. High yields were obtained and MOF-199 catalyst was easily isolated from the reaction mixture by simple filtration and reused with loss in activity.
