The study of religious values and beliefs as one of the dimensions of humanity, including self-awareness and self-knowledge of the past era has been the focus of historians. In the past, religious beliefs were considered only as an individual aspect, but this discussion in historical texts has also considered the effects of religious beliefs on its social life aspects. The present report uses a descriptive-analytical method to study the relationship between religious beliefs and how to deal with disease by exploring infectious diseases based on historical information. The core of the present research outcomes is that: Many writers attributed these calamities or divine calamity or calamity and wrath that they were caught in due to sin and the atonement for their sins was that has been revealed by God from people's point of view. This indicates that the since people still considered these calamities as a divine destiny against which they were powerless and surrendered, and did not take any action to prevent or cure them or try to eliminate them.