Aims: Exercise training is one of the nonpharmacological treatments for heart heart diseases. The aim of this study was to investigate the effect of eight weeks of endurance rehabilitation training on apoptosis among cardiac patients. Methods and Material: Sixteen POST CABG patients, having examined by specialists, were randomly assigned to control (n = 8) and experimental groups (n = 8). The experimental group completed a training protocol including running on a treadmill at 55 to 70 percent of their maximum heart rate for 8 weeks. Blood sampling was performed after 12 to 14 hours of fasting and before and after the 8 weeks of training in order to measure biochemical variables. The measurement of Bax and Bcl-2 was conducted using the ELISA kit. The data analysis was carried out using the independent-samples t-test at p ≤ .05. Results: The results showed a significant difference between the participants’ mean Bax (p=0.011) and Bcl-2 (p=0.015) values after the intervention for both groups. Likewise, the difference between the ratios of Bcl-2/Bax values after the intervention was significant for both groups (p=0.023). Conclusions: According to the findings of the study, it seems that the endurance rehabilitation training exercises could have a protective effect against apoptosis.
