Abstract: Objective: Burns can be physically and mentally painful, making them one of the worst experiences. In this study, hydroalcoholic extracts of Thymbra spicata and Ferulago angulata were investigated as treatments for second-degree burns in male Wistar rats. Methods: To create the burn wounds, a circular metal tool with a diameter of 2 cm was used, followed by treatment with prepared ointments including Ferulago angulata (1%), Thymbra spicata (1%), Thymbra spicata plus Ferulago angulata (1%), and Adib derm ointment. The wound area was measured and the wound tissue was examined histopathologically on days 1, 7, 14, and 21 in each group. The ointments were applied every day for 21 days to determine the wound healing rate. Results: The experiment showed that on the sixth and eleventh days, the groups treated with a combination of Ferulago angulata and Thymbra spicata, and Ferulago angulata alone, demonstrated significant reductions in wound area. According to histopathology, both Ferulago angulata alone and in combination with Thymbra spicata significantly improved the inflammatory condition, epithelialization process, fibroplasia, arrangement, and density of collagen fibers when compared to the other groups. Conclusion: The study showed that Ferulago angulata extract, either on its own or in combination with Thymbra spicata extract, has significant healing and restorative effects on seconddegree burn wounds in animal models
