Ni0.35Cu0.25Zn0.4Fe2O4 MNPs were synthesized using tragacanth gum as biotemplate and Metals nitrate as the metal source by the sol–gel method. The sample was characterized by powder X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), vibrating sample magnetometer (VSM), scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX). The nanoparticles exhibit ferromagnetic behaviour at room temperature, with a saturation magnetization of 52.76 emu/g and a coercivity of 80.14 Oe. Thereupon, Ni-Cu-Zn ferrite nanoparticles as an efficient catalyst was used for the synthesis of polyhydroquinoline derivatives via multi-component reactions under microwave irradiation. Simple work-up, mild reaction conditions, short reaction times, use of an economically convenient catalyst, and excellent product yields are the advantageous features of this method. The catalyst could easily be recycled and reused few times without noticeable decrease in catalytic activity.
