Triarylimidazole compounds have gained remarkable importance due to their widespread biological activities and their use in synthetic chemistry. Imidazole ring system is one of the most important substructures found in a large number of natural products and pharmacologically active compounds such as antiulcerative agent cimetidine1, the proton pump inhibitor omeprazole2 and the benzodiazepine antagonist flumazenil3 are imidazole derivatives. In this work, synthesis of Cu0.5Zn0.5Fe2O4@ZnO magnetic nanoparticles was performed by the green sol–gel method using natural gel. The sample was characterized by Fourier transform infrared spectrophotometer (FTIR), X-ray powder diffraction (XRD), vibrating sample magnetometer (VSM), Transmission electron microscopy (TEM), Field emission scanning electron microscopy (FESEM) and energy dispersive X-ray analysis (EDX). XRD results show that Cu0.5Zn0.5Fe2O4@ZnO MNPs corresponds to the hexagonal of ZnO and the spinel cubic structure of Cu0.5Zn0.5Fe2O4. Cu0.5Zn0.5Fe2O4@ZnO magnetic nanoparticles were used as a reusable and robust heterogeneous catalyst for one-pot three-component reaction of benzyl, aldehydes, and ammonium acetate in solvent free condition under microwave irradiation (scheme 1). The final product was investigated by 1H NMR and 13C NMR spectroscopy. The present methodology offers several advantages, such as excellent yields, shorter reaction times, economic availability, and reusability of catalyst.
