In recent years, there has been increasing interest in the Biginelli reaction for synthesizing octahydroquinazolinones. This reaction involves replacing open-chain dicarbonyl compounds with cyclic β-diketones and utilizing concentrated H2SO4 and HCl as catalysts. Octahydroquinazolinone derivatives synthesized through this method have garnered significant attention due to their diverse pharmacological properties [1]. The presence of the quinazolinone moiety in these compounds makes them valuable for applications such as hypnotic/sedative drugs and cancer treatment. Furthermore, quinazolinone derivatives exhibit a wide range of biological activities, including analgesic, anti-inflammatory, antimicrobial, anti-tubercular, anti-HIV, antimalarial, and antihistamine effects [2]. In this work, a simple, efficient and cost-effective method for the synthesis of octahydroquinazolinone derivatives using dimedone, urea and aromatic aldehydes using copper- magnesium ferrite as a catalyst under solvent free condition in microwave irradiation is reported. The present method does not involve any hazardous organic solvents. This catalyst has promising features for the reaction response such as the shortest reaction time, excellent product yields, simple work-up procedure and purification of products by non-chromatographic methods.
