In this study, Mn2O3 nanoparticles were synthesized through a green method without using any organic chemicals. These nanoparticles were utilized as an efficient catalyst for the synthesis of 1,8-dioxo-octahydroxanthene derivatives via a solvent-free, multi-component reaction under microwave irradiation. Dimedone (2 mmol) and benzaldehyde (1 mmol) were used as starting materials (Scheme 1). The method offers several advantages, including environmental friendliness, high yields, and a simple work-up procedure. Furthermore, the Mn2O3 catalyst demonstrated excellent reusability, retaining high catalytic efficiency after several cycles.