Abstract: Background: Metabolic syndrome, which is characterized by a constellation of well-- known risk factors, including obesity, hyperlipidemia, insulin resistance, and hypertension, is associated with an elevated risk of developing diabetes and cardiovascular disease. Given the lifestyle change, the prevalence of metabolic syndrome has been growing worldwide in recent years. Accordingly, the pivotal role of diet in the progression of metabolic syndrome as a lifestyle modification is taken into account. Aims: This systematic review aimed to explore the association of blueberry consumption with ameliorating metabolic syndrome. Methods: We conducted this systematic review under PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and performed a systematic literature search in several databases, including Web of Science, Scopus, PubMed, and Google Scholar. Results: Six clinical trial studies indicated that blueberries could not change components of metabolic syndrome, especially blood glucose. However, most of the animal studies indicated the protective effects of blueberries on these components. Conclusion: There are evidence suggesting that blueberry may effectively impact metabolic syndrome, whereas some disputed findings have shown that there is no alteration of metabolic syndrome components. Further clinical trials are needed to be conducted to investigate the potential impact of blueberries on metabolic syndrome and address this question.
