Background: Vincristine(VIN) has been broadly used in the clinic for the treatment of various cancers. This drug has toxic effects on the tissues, specially the genital organs. One of the most important side effects is the induced-changes in the female’s reproductive system which may lead to infertility. The purpose of this study was to investigate the antioxidant effects of CoA Q10 on the induced -toxicity of vincristine on embryos developing process in Vitro fertilized mice. Materials and Methods: In this experimental study for 21 days, 32 female mice with 20- 25gr weight were divided into 4 groups(n=8). The control group received normal saline (0.1 ml/kg,ip/day), and Sham control group received VIN alone (3mg/kg,ip/week) and experimental group received CoA Q10 (22mg/kg,ip/day) along with VIN(3mg/kg,ip/week).The positive control group received CoA Q10 (22mg/kg,ip/day). After the end of treatment, ovulation stimulated by PMSG and HCG.The sperms were obtained from 10 mature male mice. Animals were anesthetized to killing easily, oocyte and normal sperm were obtained and fertilized in culture medium, then incubated for 120 hours in presence of HTF+4 mg BSA, and embryonic development was examined. Finally, obtained data was analyzed using the SPSS16 software. Results: Vincristine caused a significant decrease in oocyte quality, fertilization rate, embryo developmental stage before implantation and embryo quality. CoA Q10 significantly reduced toxic effects of vincristine. Conclusion: The present study showed that CoA Q10 can protect the reproductive ability of females against vincristine damage.
