The goal of this research is the development of a solid phase microextraction based on monolithic molecularly imprinted polymer fiber (SPME-MMIPF) method to determine 229 pesticides in edible oil samples using gas chromatography-mass spectrometry (GC-MS) and comparison of it with the common QuEChERS method. For SPME-MMIPF method, an MMIPF was synthesized by polymerization of methacrylic acid in presence of ethylene glycoldimethacrylate and azo (bis)-isobutyronitrile. The optimal conditions for the SPME-MMIPF method are: extraction time 30 min, desorption time with toluene 20 min and string speed of the aqueous sample 600 rpm. Under optimal extraction condition, the figures of merit were obtained for two methods and compared. The linear range of 1–300 μg kg− 1 for SPME-MMIPF and 10–250 μg kg− 1 for QuEChERS was obtained. The detection limits of SPME-MMIPF (0.300–0.335 μg kg− 1) method was better than the QuEChERS (0.9–2.8 μg kg− 1) method. The results showed a quantification limit of 0.990–1.102 μg kg− 1 for SPME-MMIPF and 3.0–9.2 μg kg− 1 for QuEChERS. The recoveries were in the range of 92–102% and 68–127% for SPME-MMIPF and QuEChERS, respectively
