In this research, the influences of garlic extract (GE) (0%–3%), cholesterol‐to‐lecithin ratio (CLR) (0–1), and sonication duration (10–30 min) were thoroughly examined concerning the physicochemical and antimicrobial properties of phytosomal‐nanocarriers (PNCs). Fourier‐transform infrared (FT‐IR) analysis was conducted to ascertain the presence or absence of interactions between the GE and other constituent elements. The parameters of particle size, zeta potential, encapsulation efficiency, turbidity, and stability were all significantly influenced by the duration of sonication, and a robust correlation was established among these variables. The pH levels and electrical conductivity exhibited a significant dependency on the concentration of GE and the CLR. PNCs infused with GE manifested antimicrobial and antioxidant properties, likely attributable to the diminutive particle size and the elevated penetration …