The benefits of foliar nitrogen feeding and exogenous cytokinin application on wheat performance, particularly their effects on grain yield and grain nutrient content, are of considerable importance. A field experiment was conducted to evaluate the efficacy of foliar urea and 6-benzylaminopurine (6-BAP) application on grain nutrient composition and yield in the ‘Saji’ wheat cultivar during the 2021–2022 growing season in Sirvan County, Ilam Province, Iran. The experiment followed a 4 × 2 factorial arrangement, with three replications. Urea was foliar-applied at four concentrations (0%, 2%, 3%, and 4%, w/v), while 6-BAP was applied at two levels (0 and 100 mg L–1 ). Foliar spraying was performed at the late flowering stage. Results indicated that the highest number of grains per spike (37.2) was obtained with the 3% (w/v) urea treatment, while a higher concentration (4%, w/v) negatively affected this trait. The greatest total grain weight per spike (1.77 g) and 1000-grain weight (47.8 g) were achieved with 3% (w/v) urea combined with exogenous 6-BAP application. The maximum grain yield (2180 kg ha–1 ) was also recorded under this treatment. Additionally, the highest grain nitrogen (1.5%) and Zn (46.2 mg kg–1 ) contents were observed with 3% urea application. These findings suggest that the foliar application of urea at lower concentrations, in combination with 6-BAP, represents an effective approach for enhancing grain yield and quality in durum wheat.